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Failure of Delayed Feedback Deep Brain Stimulation for Intermittent Pathological Synchronization in Parkinson’s Disease

Figure 6

Change in the number of PCA components in a network with feedback stimulation.

The spatial set-up of stimulation is different from that in Figure 5. A, B) 30% or 50% of STN neurons are directly affected by stimulation. Electrode is placed near the 5th STN neuron. C, D) 40% or 60% of STN neurons are directly affected by stimulation current, correspondingly. Electrodes are placed near the 5th and 6th STN neurons. E, F) 70% or 90% of STN neurons are directly affected by stimulation current, correspondingly. Electrodes are placed near the 5th, 7th and 9th STN neurons. Weight parameters are w1 = 0.3, A, C, E) w2 = 0; B, D, F) w2 = 0.1. Iapp = 5 in all simulations.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0058264.g006