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Genome-Wide Association Analysis Identifies a Mutation in the Thiamine Transporter 2 (SLC19A3) Gene Associated with Alaskan Husky Encephalopathy

Figure 2

Brain of dog #6.

A. Transverse section of brain with bilaterally symmetrical areas of cavitation due to encephalomalacia in the thalamus. B. Same dog; macrophotograph of a transverse section of brain rostral to Figure 2A illustrating bilaterally symmetrical areas of polioencephalomalacia [2] or of necrosis with incipient malacia [1], [3], [4] in cortex deep in the sulci [1], in the claustrum [2], in caudate nucleus [3] and the globus pallidus [4] (HE-LFB stain).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0057195.g002