Metabolic Profiling for Detection of Staphylococcus aureus Infection and Antibiotic Resistance
Figure 3
Discrimination between the metabolic profiles of S. aureus and E. coli sepsis in humans and effect of antibiotic treatment.
A) OPLS-DA predictive score plot (score vectors t [1] p vs. t [2] p) for a four class model based on 228 metabolites revealing discrimination of severe sepsis caused by S. aureus or E. coli in the acute phase. B) Cross-validated and predicted OPLS-DA predictive score values, tPS [1] cv [1] p, for a two class model, based on 37 metabolites for discrimination of S. aureus and E. coli infection (p = 0.052). Out-of-sample prediction of sera of four patients at two time points. Mean score values with 95% CI are shown.