Chemoresistance of Human Monocyte-Derived Dendritic Cells Is Regulated by IL-17A
Figure 2
Comparative phenotypic analysis of monocytes, DC and IL-17A-treated DC.
Comparative study of monocytes (freshly isolated), immature DC (derived from monocytes) and IL-17A-treated DC for (A) mRNA intensities of M1 versus M2 macrophage-related genes by microarray, representative of n = 4; (B) expression (gray) of CD206 (or mannose receptor, MR) and CD163, representative of n = 3; (C) uptake of dextran FITC (MR-mediated endocytosis), in the presence of mannan competitor when indicated, mean FI values of n = 3, SD <10% not shown. Statistical significance was determined by the Mann-Whitney test, *, significant p<0.05; **, very significant p<0.01. IL-17A treatment administrated for (A) 12 days and (B,C) 48 hours.