Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components
Figure 5
Distributions of the number of pathophenotypes and pathophenotypic similarities in each subset.
MD-MG (red line), MD-PG (orange line), PD-MG (green line), PD-PG (blue line) and PSGN (Black line). Upper panels represent the cumulative frequency of the number of specific pathophenotypes annotated for genes in HDN (C) and ODN (D) subsets, the whole set of genes in HPO (PSGN) was used as the reference distribution. Lower panels represent the cumulative frequency of the average pathophenotypic similarity associated with genes in HDN (C) and ODN (D) subsets, the whole set of genes in HPO (PSGN) was used as the reference distribution. The p-values, included in each legend, represent the mean of the resulting p-values after 1000 non-parametric tests (Mann-Whitney test) where each subset was compared, each time, with a random sample of the pathophenome of the same size of the subset (see methods).