Gpr177 Deficiency Impairs Mammary Development and Prohibits Wnt-Induced Tumorigenesis
Figure 7
Gpr177 deficiency alleviates the abnormalities of mammary cell types caused by aberrant Wnt expression.
(A–U) Sections of the virgin 2 month (v2M) control (A, D, G, J, M, P, S; genotype: Gpr177Fx/+), MMTV-Wnt1 (B, E, H, K, N, Q, T; genotypes: MMTV-Wnt1; Gpr177Fx/+, MMTV-Wnt1; Gpr177Fx/Fx or MMTV-Wnt1; MMTV-Cre; Gpr177Fx/+), and MMTV-Wnt1; Gpr177MMTV (C, F, I, L, O, R, U) are analyzed by H&E staining (A–C) and immunostaining of Gpr177 (D–F), Wnt1 (G–I), K6 (J–L), K14 (M–O), K18 (P–R) and SMA (S–U). Scale bar, 50 µm (A–U).