MicroRNA Expression Profiling in HCV-Infected Human Hepatoma Cells Identifies Potential Anti-Viral Targets Induced by Interferon-α
Figure 1
MiRNA expression and validation in HCV-infected Huh7.5 cells.
(A) Heat map of differentially expressed miRNAs in uninfected and HCV-infected Huh7.5 cells using a continuous HCV culture system. Red indicates up-regulation of expression and green indicates down-regulation of expression. Seven miRNAs were down-regulated in HCV infection (p value <0.05). (B) Quantitative RTPCR (q-RTPCR) validation of differentially expressed miRNAs. (C) Specific fold change (FC) values in differentially expressed miRNAs in HCV infected Huh7.5 cells ranked by p-value.