Erlotinib Preserves Renal Function and Prevents Salt Retention in Doxorubicin Treated Nephrotic Rats
Figure 1
Doxorubicin-induced increases in water intake and urine output are reversed by Erlotinib treatment.
Shown are the changes in weight (A), urine output (B), and water intake (C) plotted over time in control rats (solid line), doxorubicin (Dox) treated rats (dotted line), and doxorubicin + Erlotinib (Dox + Erl) treated rats (dashed line). Data are expressed as means ± SE (n = 13, * p<0.05 for Dox or Dox+Erl vs. control at same time point, and for Dox or Dox+Erl vs. Dox or Dox+Erl at time 0).