IL-18 Induces Airway Hyperresponsiveness and Pulmonary Inflammation via CD4+ T Cell and IL-13
Figure 5
Deletion of IL-13 gene decreased airway inflammation, Th1 and Th2 cytokines, and airway hyperresponsiveness in IL-18 Tg mice.
WT Balb/c, IL-18 Tg, IL-13 gene deficient (KO), and IL-18 Tg/IL-13 gene deficient (TG/KO) mice were OVA-sensitized and challenged with OVA or saline. (A) Cell populations in the BALFs were calculated. (n = 14 to 20 per each group) *: p<0.05. (B) Airway responsiveness to aerosolized acetylcholine was examined as described above. The data were also expressed as airway resistance changes from baseline in response to 9 different doses of Ach (0, 0.625, 1.25, 2.5, 5, 10, 20, 40, 80, and 160 mg/ml). (n = 14 to 22 per each group) *: p<0.05.