MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells
Figure 8
A schematic diagram showing the contribution of MUC4 in the overall aggressiveness of TNBC cells.
MUC4 maintains the sustained expression of EGFR family proteins and thereby potentiates downstream signaling events mediated through the PKC-γ and Erk1/2 signaling. MUC4 maintains sustained expression of β-catenin, which induces proliferation, tumorigenesis, migration, invasion, and metastasis.