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Whole-brain Functional Networks in Cognitively Normal, Mild Cognitive Impairment, and Alzheimer’s Disease

Figure 6

Connectivity associated with left PCUN seed and connectivity reductions in CN, MCI, and AD. A.

Correlation coefficients map (R-map) showing connectivity associated with left PCUN seed in CN. B. R-map showing connectivity associated with left PCUN seed in MCI. C. R-map showing connectivity associated with left PCUN seed in AD. D. Z-statistics map showing reduced connectivity with left PCUN seed in MCI compared to CN. E. Z-statistics map showing reduced connectivity left PCUN seed in AD compared to CN (p<0.05, FDR-corrected). PCUN = precuneus; CN = cognitively normal; MCI = mild cognitive impairment; AD = Alzheimer’s disease; L = left; R = right.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0053922.g006