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NOS Inhibition Enhances Myogenic Tone by Increasing Rho-Kinase Mediated Ca²⁺ Sensitivity in the Male but Not the Female Gerbil Spiral Modiolar Artery

Figure 5

LNNA increases the Ca²⁺ sensitivity in male but not female SMAs and DEA-NONOate reverses the LNNA effect in male SMAs.

A) Ca²⁺ sensitivity in female SMAs in PSS and 10 µM LNNA. B) Ca²⁺ sensitivity in male SMAs in PSS and 10 µM LNNA. C) Ca²⁺ sensitivity in female SMAs in 10 µM and 100 µM LNNA. D) Ca²⁺ sensitivity in male SMAs in PSS and in 10 µM LNNA + 8 µM DEA-NONOate. Numbers next to symbols represent the number of SMA segments and error bars represent sem. Average FC₅₀ ± sem are given and significant differences in the FC₅₀ values are marked (star).

doi: https://doi.org/10.1371/journal.pone.0053655.g005