Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1α Pathway
Figure 2
K5 suppresses pulmonary metastasis of LLC.
(A) The surface nodules on mouse lung (left, marked by black arrow) and quantitative analysis (right, *P<0.01, vs PBS control group). (B) Micrometastases in lung observed with high power microscope (×200) and quantitative analysis (*P<0.01, vs PBS control group). (C) Pulmonary alveoli observed with low power microscope (×20) and quantitative analysis of pulmonary alveoli area in lung (*P<0.01, #P<0.05; a: vs normal control group, b: vs PBS control group).