Anti-Amyloid-β-Mediated Positron Emission Tomography Imaging in Alzheimer's Disease Mouse Brains
Figure 4
Examination of brain tissue post-mortem confirms higher accumulation of intravenously injected 6E10-64Cu in TgCRND8 than wild type mice.
(A) Post-mortem biodistribution analysis of all organs 12 h after intravenous injection does not distinguish between TgCRND8 and wild type brain tissue, but does reveal accumulation and removal in liver, kidneys, and gastrointestinal organs (n = 3, mean ± standard deviation plotted). (B) Ratio of % injected dose per gram of tissue TgCRND8 to wild type brain tissue, as measured by gamma counting and PET quantitation, confirms higher accumulation in TgCRND8 than wild type mice 2 h after injection with 6E10-PEG. (n = 3, mean ± standard deviation plotted).