Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis
Figure 3
Longitudinal follow-up of P. aeruginosa genotypes in CF lungs.
Course of chronic airway infections with P. aeruginosa since onset of colonization in patients with CF seen at the CF clinics Hannover (H1– H35, Fig. 3A) and Copenhagen (K1– K12, Fig. 3B). The most common clones are marked in different colours (eight for Hannover and four for Copenhagen), all other clones are marked in grey (Hanover: black = clone C40A, light green = clone 7C9A, light blue = clone 3C2A, orange = clone 1BAE, pink = clone 6D92, blue = clone D421, brown = clone 0C2E, purple = clone AC9A; Copenhagen: red = clone 6822, green = clone 4022, brown = clone 2C22, blue = clone AE9A). If no isolates were available from the Hannover CF clinic in 2010, patients had previously moved to another region (H2, H22, H23, H24, H27, H30, H31, H32), had passed away or had received a lung transplantation (H1, H3, H4, H11, H13, H14, H19, H26, H28, H29). Patients H33, H34 and H35 were only transiently colonized with P. aeruginosa. At the Copenhagen clinic 5 patients got a lung transplantation between 1996 and 2004, 5 other patients died (1999–2008). One of the deceased patients had also a lung transplantation, so that in total 9 patients have either died or received a lung transplantation.