Fatp1 Deficiency Affects Retinal Light Response and Dark Adaptation, and Induces Age-Related Alterations
Figure 4
The visual cycle in 5 to 8 mo-old Fatp1−/− mice.
A. Expression levels of the main visual cycle genes, Rpe65, Lrat and Rdh5. Bars represent the mean of triplicates ± SEM. * p<0.05. The genes were slightly deregulated with a 9.6% increase observed for Rpe65, a 12.5% increase for Lrat and a 19.5% increase for Rdh5. B. Recovery of the b-wave amplitude after bleaching in 5 to 8 mo-old mice (n = 29 Fatp1+/+ and n = 21 Fatp1−/−). Error bars represent SEM. * p<0.05. C. Quantification of the 11-cis retinal and all-trans retinal levels in the whole eye. Error bars represent SEM. The recovery of the electroretinogram is delayed in Fatp1−/− mice but this difference is not linked to a visual cycle kinetic defect.