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Exon 1 Disruption Alters Tissue-Specific Expression of Mouse p53 and Results in Selective Development of B Cell Lymphomas

Figure 8

B cell lymphomas do not develop in p53^rev/revCD19-Cre⁺ mice.

A) The B cells of p53^rev/revCD19-Cre⁺ and p53^rev/revCD19-Cre⁻ mice were isolated from splenocytes with MACS systems. The purified B cells were irradiated and cultured for three hours at 37°C. The lysates of B cells were immunoblotted with anti-p53 antibodies. B) B cell lymphoma incidence was determined in p53^rev/revCD19-Cre⁺ and p53^rev/revCD19-Cre⁻ mice followed for 9 months.

doi: https://doi.org/10.1371/journal.pone.0049305.g008