Environmental Enrichment Enhances Episodic-Like Memory in Association with a Modified Neuronal Activation Profile in Adult Mice
Figure 1
Brain activation experimental design. A.
After 3 weeks in either standard condition (SC) or enriched condition (EC), memory performances of mice were tested in an object-recognition task performed in a Y-maze with an inter-session interval (ISI) of 24 h (“Test” groups, n = 12 for each housing condition). B. Ninety minutes after the presentation or after the test session, animals were euthanized and the brains were collected for c-Fos immunohistochemistry (“Presentation” groups and “Test” groups, n = 10 per housing condition). Additional mice were exposed to the same behavioral procedures but without any object (“Control of presentation” groups and “Control of test” groups, n = 8 and n = 10 per housing condition respectively).