Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response
Figure 2
Immunohistochemical analysis of macrophage infiltration in 1-week-old wild type (OCTN2+/+) and homozygous (OCTN2−/−) mice ileum sections.
Panel A is an ileum section showing F4/80 staining (brown) of villous macrophages from the wild-type mouse and panel C is a high power magnification of a representative area to help count the number of F4/80 positive cells. Panel B is an ileum section of a homozygous mouse and panel D is a high power magnification of a representative area. Panel E is a graphic representation of the number of F4/80 positive cells in each section (Bar represents 100 µm).