Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells
Figure 2
AA005 inhibits cell growth/proliferation, suppresses colony forming activity and arrests cell cycle in colon cancer cells.
(A, B) Indicated cells were treated with or without AA005 for 48 h or indicated time points, and analyzed by trypan blue exclusion assay. (C) Colony formation assay for the clonogenic activity of colon cancer cells treated with or without AA005. (D) Colon cancer cells were treated with AA005 at indicated concentrations for 24 h. Cell cycle distribution was determined by flow cytometry.