Negative Coupling as a Mechanism for Signal Propagation between C2 Domains of Synaptotagmin I
Figure 7
Location of tryptophan residues (orange) in C2A (purple) and C2B (green).
Two of three tryptophan residues (C2A’s and one of C2B’s) occupy superficial positions and may, as a result, be more solvent exposed in solution (left). The second tryptophan in the C2B domain is partially embedded in the core of the β-sandwich motif amongst several hydrophobic residues (yellow) (right). The differences in tryptophan environment likely give rise to unequal FLT signal contributions, with most of the signal coming from C2B’s β-sandwich residue.