Age-Related Expansion of Tim-3 Expressing T Cells in Vertically HIV-1 Infected Children
Figure 2
Expansion of Tim-3+ CD4+ T cells in perinatally HIV-1-infected adolescents.
(A) Flow dot plots show CD4+ T cell surface expression of CD28 and CD57 in perinatally HIV-1-infected children with shorter duration of HIV-1 infection (median: 11.2 y) and adolescents with longer duration of HIV infection (median:18.5 y). (B) Frequencies of CD28−, CD57+, and CD57+CD28− CD4+ T cells in perinatally HIV-1-infected children and adolescents. (C) Flow dot plots show CD4+ T cell surface expression of PD-1 and Tim-3 in perinatally HIV-1-infected children with shorter duration of HIV infection (median: 11.2 y) and adolescents with longer duration of HIV-1 infection (median: 18.5 y). (D) Frequencies of Tim-3+, PD-1+, and PD-1+ Tim-3+CD4+ T cells in perinatally HIV-1-infected children and adolescents. A significant increase in Tim-3+CD4+ T cell (**p = 0.003) population was observed with age. P values were obtained using two-tailed Mann-Whitney U test. Flow dot plots are representative of all subjects in respective groups.