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Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells

Figure 5

C57/BL6 iPSC-derived GFP+ Flt1+/Flt4+ CPCs transplanted into strain-matched hearts engraft and robustly differentiate into CMs and smooth muscle cells.

Post-injection immunofluorescence imaging of GFP+ Flt1+/Flt4+ CPCs transplanted into the left ventricle of C57/BL6 mice demonstrates in vivo engraftment and robust differentiation into CMs and smooth muscle cells. (A & B) Immunostaining of GFP+ Flt1+/Flt4+ injected myocardial sections for CMs: (a,d) single channels for GFP and (b,e) single channels for TropC with (c,f) merged images. (C) Immunostaining of GFP+ Flt1+/Flt4+ injected myocardial sections for smooth muscle cells: (g) single channel for GFP and (h) α-SMA along with (i) merged images.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0045603.g005