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Directional Migration of Recirculating Lymphocytes through Lymph Nodes via Random Walks

Figure 3

Inferred smoothed distributions of migration times obtained by on combined data sets.

Each sampled training set is optimised over to determine the necessary extent of smoothing, and this sampling is repeated fifty times. The optimal distribution in each case is that which gives the lowest SSE on the test set out of all fifty samples. The optimal distributions shown here are based on sampling (a) three and (b) nine data sets to form the training set. (c and d) Piecewise 95% confidence intervals for optimal distributions of migration times. Each bar gives a 95% confidence interval for the mean probability of migration occurring within each two-hour interval based on fifty random samples of (c) three and (d) nine concatenated data sets to form the training set. (e) Similar analysis showing inferred smoothed distribution using CD4+ cells only (four samples).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0045262.g003