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The Zebrafish Homologue of the Human DYT1 Dystonia Gene Is Widely Expressed in CNS Neurons but Non-Essential for Early Motor System Development

Figure 3

A: Syntenic relationships of tor1, TOR1A and TOR1B.

The diagram shows the order and orientation of genes flanking TOR1A and TOR1B in the human and xenopus genomes, and tor1 in the coelacanth genome. The map is shown to scale; large arrows show the direction of the telomere. TOR1A, TOR1B and tor1 are colored black. The flanking genes are colored green (USP20), red (FNBP1), blue (C9orf78), orange (PTGES) and lilac (PRRX2). Orthologous genes are connected by solid lines. B: The diagram shows the order and orientation of genes flanking tor1 in the zebrafish, fugu, stickleback, and tetraodon genomes. The color scheme is identical to panel A; additional flanking genes are colored as follows: dark grey - conserved chromosomal positions in all four fish species; light grey - conserved chromosomal positions in two or three fish species; white - chromosomal position not conserved.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0045175.g003