The Synergistic Effect of Chemical Carcinogens Enhances Epstein-Barr Virus Reactivation and Tumor Progression of Nasopharyngeal Carcinoma Cells
Figure 5
Differentially expressed genes in NPC cells after recurrent EBV reactivation corresponded to the alterations observed in NPC biopsies.
(A) Differentially expressed probe sets of NA-P10/TS-MG and NA-P1/mock, and 31 NPC and 10 normal biopsies (GSE12452). The intersection between two data sets yielded a 36 common probe set which was presented in both groups. (B) Expression profile of 28 genes (derived from the 36 common probes) that were differentially expressed in NPC cell lines and biopsies. Hierarchical clustering was performed by shifting genes to mean of zero and scale to standard deviation of one. (C) Expression profile of five carcinogenesis-related genes in 31 NPC and 10 normal biopsies. Each circle represents the expression level of an individual biopsy. Boxplot indicates the median (central band) and the 10th and 90th percentile (lower and upper whiskers, respectively) of expression level. ZNRF3: zinc and ring finger 3; PI3: peptidase inhibitor 3, skin-derived; TJP3: tight junction protein 3; ALDH3A1: aldehyde dehydrogenase 3 family, member A1; MGLL: monoglyceride lipase.