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A Neonatal Model of Intravenous Staphylococcus epidermidis Infection in Mice <24 h Old Enables Characterization of Early Innate Immune Responses

Figure 6

SE induces selective mRNA expression of TLR2 and MyD88.

Liver samples were collected 2 h post-SE injection and analyzed for mRNA expression of TLR2, TLR4, MyD88, and MD-2. Relative fold change in mRNA transcripts, each normalized to housekeeping genes as described in methods, was expressed as a ratio of each transcript in the SE injected animals to that in saline-injected animals. SE induced significant inoculum-dependent increases in mRNAs encoding TLR2 and MyD88 (* p<0.05, Student t-test). By contrast, TLR4 and MD-2 were not up-regulated over saline-injected mice.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0043897.g006