The Effect of Hepatic Encephalopathy, Hepatic Failure, and Portosystemic Shunt on Brain Volume of Cirrhotic Patients: A Voxel-Based Morphometry Study
Figure 3
Brain volume changes with Child-Pugh scale and portosystemic shunt.
Compared with patients with Child-Pugh A, patients with Child-Pugh B plus C showed decreased gray volume in the frontal, parietal and temporal cortex (Panel at Line 1). Patients with high portosystemic shunt scores (≥4) displayed decreased gray matter volume in the anterior cingulate cortex (ACC) and precuneus, and increased white matter volume in the parietal lobe, internal capsule, and cerebellum crus, when comparing to those with low portosystemic shunt scores (Panels at lines 2 and 3). Compared with pre-TIPS, post-TIPS patients displayed decreased gray matter volume in the ACC, cerebellar vermis, increased gray matter volume in the thalamus, and increased white matter volume in bilateral posterior periventricular white matter (Panels at lines 4 and 5). (P<0.01, FDR corrected). GM = gray matter; WM = white matter; TIPS = transjugular intrahepatic systemic shunt; R = right; L = left.