iNKT Cells Suppress the CD8+ T Cell Response to a Murine Burkitt’s-Like B Cell Lymphoma
Figure 5
In the absence of iNKT cells, CD8+ T cells are required for tumor clearance.
(A and B) The frequency of tumor cells in the spleens of tumor transplanted Jalpha18−/− mice treated with control (anti-human DR1), anti-NK1.1, anti-CD8, or both anti-NK1.1 and anti-CD8 antibodies was measured by flow cytometry. Plots in (A) are gated on CD49b-NK1.1-CD4-CD8- cells and the number on each plot indicates the frequency of tumor cells in that gate. (B) The frequency of tumor cells among splenocytes for the indicated antibody-treated Jalpha18−/−mice is shown. (C) The number of tumor cells present in spleens of antibody treated mice was determined (n = 6–8 pooled from 2 independent experiments). *p<.05. **p<.01.