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Low Molecular Weight Heparin Ablates Lung Cancer Cisplatin-Resistance by Inducing Proteasome-Mediated ABCG2 Protein Degradation

Figure 3

Flow-cytometry analysis of CSC marker expression induced by LMWH in A549/DDP side population (SP) cells or in A549/DDP SP xenograft tumor cells.

(A) Expression of ABCG2 (CD338) in control SP cells and (B) induced by LMWH in A549/DDP SP cells. (C) Expression of ABCG2 (CD338) in controls tumor cells and (D) induced by LMWH in A549/DDP SP xenograft tumor cells. (E) Quantification of expression of CSC marker expression induced by LMWH in SP cells and xenograft tumor cells. LMWH significantly downregulated expression of ABCG2 by FACS (p<0.05).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0041035.g003