The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background
Figure 4
Phenotypic characterization of high fat fed male C57BL/6J Slc30a8 KO mice.
Male WT (n = 5; mean age 44.6 weeks), heterozygous (HET) (n = 14; mean age 39.6 weeks) and KO (n = 6; mean age 49.5 weeks) mice were fed a high fat diet with body weights measured weekly (Panel A). After 8 weeks mice fasted for 4 hours and then weighed. One hour later mice were anesthetized and blood was isolated. Blood glucose (Panel B) and plasma cholesterol (Panel C) and insulin (Panel D) levels were determined as described in Materials and Methods. One week later IPGTTs were performed on 6 hr fasted conscious C57BL/6J WT (closed symbols) and Slc30a8 KO (open symbols) male mice as described in Materials and Methods (Panel E). Results represent mean data ± S.E.M. *p<0.05 versus WT.