The Pro-Inflammatory Cytokine IL-22 Up-Regulates Keratin 17 Expression in Keratinocytes via STAT3 and ERK1/2
Figure 5
The synergism of IL-22, IL-17A and IFN-γ in inducing K17 expression.
HaCaT were treated with IL-22(25 ng/ml), IL-17A (100 U/ml) and IFN-γ (100 U/ml) alone or in combination. (A) The real-time PCR analysis of K17 mRNA levels after 24 h; Data are expressed as 2−ΔΔCT relative to untreated HaCaT cells. (B) The Western blot analysis of K17 protein expression. The blank group is untreated HaCaT cells. Results represent means±SEM from three independent experiments. *P<0.05 was considered significant.