Inferring Proteolytic Processes from Mass Spectrometry Time Series Data Using Degradation Graphs
Figure 1
Degradation of a beta-2-microglobulin fragment observed via Mass Spectrometry.
Mass spectra generated during the degradation of a beta-2-microglobulin fragment by a mixture of urine proteins after 7 (upper) and 24 (lower) hours of incubation. Intensity is given in percent of maximal peak intensity. In the lower spectrum all fragments were annotated that could be verified by MS/MS identifications. Details of data acquisition and sample preprocessing are given in the results section. All raw spectra of this time series are shown in the Supporting Information (Figure S2).