BF066, a Novel Dual Target Antiplatelet Agent without Significant Bleeding
Figure 4
BF066 inhibits cAMP-phosphodiesterase activity in human platelet extracts.
BF066 concentration-dependently inhibited activity of PDE extracted from human platelets. A) Representative HPLC tracings of residual cAMP in the presence of PDE and various inhibitors. B) BF066 concentration-dependently inhibited activity of PDE extracted from human platelets. Data were shown as mean ± SEM representing four separate experiments.