Proteomic Identification of Calumenin as a G551D - CFTR Associated Protein
Figure 4
UPR is likely triggered in G551D-CFTR expressing cells.
A, Example of detection of Grp78 in Wt-CFTR, Fdel508-CFTR and G551D-CFTR expressing cells, assessed by western blotting using whole cell lysates. A Fdel508-CFTR expressing cell lysate was used as a positive control. B, Histogram represents the quantitation indicating that the amount of Grp78 is increased in Fdel508-CFTR and G551D-CFTR expressing cells whereas no difference is observed between Fdel508-CFTR and G551D-CFTR expressing cells (right).