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Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo

Figure 5

AS-IV ameliorated the renal histopathology in diabetic rats at 12 weeks after STZ injection.

AS-IV treatment (2.5, 5, 10 mg·kg−1·d−1) was started 2 weeks before STZ injection and lasted 14 weeks. NC, normal control rats; DN, STZ-induced diabetic rats; AL, DN rats treated with AS-IV (2.5 mg·kg−1·d−1); AM, DN rats treated with AS-IV (5 mg·kg−1·d−1); AH, DN rats treated with AS-IV (10 mg·kg−1·d−1).

Figure 5

doi: https://doi.org/10.1371/journal.pone.0039824.g005