Genome-Wide Screening for Genetic Alterations in Esophageal Cancer by aCGH Identifies 11q13 Amplification Oncogenes Associated with Nodal Metastasis
Figure 1
Whole genome profile of an ESCC cell line (EC18) by 1-Mb aCGH.
Normalized log2 signal intensity ratios were plotted using SeeGH software. A log2 signal ratio of 0 represents equivalent copy number between the sample and the reference DNA (details in Materials and Methods). Cytoband pattern for each chromosome is shown in the left. Vertical lines denote log2 signal ratios from −2 to +2 with copy number increasing in the right and decreasing in the left. Each dark blue dot represents a single BAC clone.