Angiotensin II-Induced Mitochondrial Nox4 Is a Major Endogenous Source of Oxidative Stress in Kidney Tubular Cells
Figure 7
Ang II-induced mitochondrial Nox4.
A, Western blotting of Nox4 in the mitochondrial fraction, subcellular membrane fraction, and cytosolic fraction of NRK-52E cells exposed to Ang II (10−6 M) with or without Ang-(1-7) (10−6 M), A779 (10−6 M), and apocynin (100 µM). B, Nox4 colocalizes with the mitochondrial marker Mitotracker Red FM. Values are the mean ± S.E.M. (n = 4).