Secreted Phospholipase A2 Involvement in Neurodegeneration: Differential Testing of Prosurvival and Anti-Inflammatory Effects of Enzyme Inhibition
Figure 4
Phagocytosis activity and cytokine levels of macrophages differentiated from HL-60 cells.
Most macrophages in vehicle group were labeled with red beads and the intensity of beads was high (A). Macrophages treated with CHEC-9 engulfed significantly fewer beads after 4 days differentiation and resulted in a lower percentage of cells containing beads. Quantification of the results (C, D). Decreased expression of TNF-α and IL-6 by 50–60% was found in the cell medium of CHEC-9 treated group (E). (** p<0.005).