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UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection

Figure 6

Effect of the 3d mutation on viral clearance.

Livers were harvested from C57BL/6 (WT) or 3d mice that were either uninfected or infected for 3, 5, 7 or 9 days with MCMV (5×104 PFU). Viral titers were determined using a standard plaque assay. The level of detection of the plaque assay is 2 log PFU/g liver (dashed line). Each data point represents an individual WT (filled diamonds) or 3d mouse (open circles). Data from days 0, 3, 5, and 7 are the combined results of three independent experiments (n = 4–7 mice per group). In data from day 9, n = 5 mice per group. Asterisks denote a significant difference between WT and 3d mean PFU/g liver (p values≤0.04).

Figure 6

doi: https://doi.org/10.1371/journal.pone.0039161.g006