Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin
Figure 3
The distribution of α-cells and δ-cells following STZ treatment.
The pancreatic islets from normal and STZ-treated mice were co-stained with anti-glucagon (green) and anti-somatostatin (red) antibodies. A: representative images showing δ-cells expanded in a similar pattern to α-cells following STZ treatment. B: Quantitative distribution of δ-cells in each islet group. The quantification of δ-cells was obtained the same way as described for α-cells and β-cells in Figures 1 and 2. The redlines represent the mean values for each islet group. C: the statistical summary of δ-cell distribution in islets from normal mice and STZ-treated mice. The mark ** indicates p<0.005, and *** indicates p<0.0005; ns: not significant.