Integrated Analysis of Gene Expression and Tumor Nuclear Image Profiles Associated with Chemotherapy Response in Serous Ovarian Carcinoma
Figure 3
Tumor nuclear image profile associated with chemotherapy response.
(A) The tumor nuclear image profile demonstrates a strong association with chemotherapy response in both the training set (top) and the validation set (bottom). Each row corresponds to a morphologic feature, with the columns corresponding to data in different samples. Feature values were median centered across the tumor set and then log transformed. A detailed version of this panel with morphological feature names is provided in the Figure S5. (B) Feature (Std_Ar_Bin2) distribution across the entire image sample set (n = 253) where patients with values greater than or equal to the feature median are categorized into a group (i.e., High Std_Ar_Bin2, n = 129), and patients with values less than the feature median are categorized a different group (i.e., Low Std_Ar_Bin2, n = 124). Smaller values of Std_Ar_Bin2 feature are significantly associated with poorer OS (C) and poorer PFS (D).