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Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice

Figure 5

Effect of PPAR agonists on Myocardial lipid content.

Effect of PPAR agonists on Myocardial lipid content in CM-PGKO mice (white bars) and littermate controls (black bars) fed with standard (SD) and high fat diet (HFD). A) Oil red O staining showed an abundance of neutral lipid droplets randomly scattered throughout the cytoplasm of cardiomyocytes (original magnification, ×400). (B) Oil red O staining was quantified using Molecular Analysis Software (n = 3 in each group). # p<0.05 HFD vs SD, * p<0.05 Drug vs only diet group, +p<0.05 CTLR vs CMPGKO group.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0035999.g005