Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling
Figure 1
CCDKO mice show an early onset, focal inferior retinal degeneration starting in the outer retina which subsequently leads to a breakdown of retinal layering in the affected area with age.
In vivo assessment of the retinal degeneration of CCDKO mice and age-matched C57Bl/6 wildtype mice at 1,4,8,12,15 and older than 20 months of age using autofluorescence scanning laser ophthalmoscopy (A) and optical coherence tomography (B). Note the weak autofluorescent fundus lesions in CCDKO mice visible as early as 1 month (A) which correlate with the observation of an abnormal signal in the inferior OCT image at the same age (B) and suggests an early pathological event in the outer retina as the basis of the degeneration in this model. Corresponding signals in AF-SLO and OCT images are labelled identically. White arrowheads: small early inner retinal autofluorescent lesion, black arrowheads: discrete disciform autofluorescent lesion, white arrow: “confluent” autofluorescent lesion in AF-SLO represents loss of retinal layering and severe retinal degeneration, black arrow: discrete autofluorescent spot-like lesion. GCL: ganglion cell layer, OPL: outer plexiform layer, ONL: outer nuclear layer, RPE: retinal pigment epithelium.