The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation
Figure 2
CORM-2 attenuates P. aeruginosa biofilm formation.
A) Crystal violet (CV) biomass staining decreases after CORM-2 exposure in a dose-dependent manner. Each condition was done in triplicate. B) CV staining of PAO1 biofilms treated with 100 µM CORM-2 demonstrates decreased staining of the biofilm after 2–6 hours of CORM-2 exposure compared with DMSO vehicle where the biofilm increases overtime. C) Colony counts of PAO1 released from the iCORM (100 µM) and CORM-2 (100 µM) treated biofilms demonstrate that there is a sustainable 2-log drop in bacterial viability.