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Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

Figure 3

Directly inactivated mechanism of Kn2-7 peptide to HIV-1 PV.

Four action modes of treatment between peptides with HIV-1 PV were carried out. (1) Peptide pretreated group, TZM-bl cells were pretreated with 10 µg/ml peptide at 37°C for 1 h and then treated with HIV-1 PV. (2) Infection first group, cells were infected with HIV-1 PV first by inoculating at 37°C for 1 h and then treated with 10 µg/ml peptide. (3) Peptide/virus mixture group, cells were treated with mixture of HIV-1 PV and 10 µg/ml peptides immediately after mix but without inoculation. (4) Peptide/virus pre-incubation group, cells were infected with mixture of HIV-1 PV and 10 µg/ml peptides pre-incubating at 37°C for 1 h. The inhibitory effects of different groups were determined in TZM-bl detection system. Significant reduction in the RLU value of Kn2-7 treatment group compared with that of mucoporin-S1 treatment group are denoted by a * (p<0.05), ** (p<0.01), and *** (p<0.001).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0034947.g003