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A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

Figure 1

Calculated powers for simulated genome-wide homozygosity association scans.

The simulated genome-wide homozygosity association scans included 2,000 patients and 3,000 controls and used −log10(p)>8 for the threshold of statistical significance. Parameters for the calculations included: The proportion of patients carrying the ROH (δ = 0.1, 0.2, or 0.3) controlled the effective size of a scan. The number of evenly spaced SNPs (L = 100, 150, or 200 SNPs) determined the length of the true disease-associated ROH. The heterozygous interference was defined as the fraction of heterozygous-call SNPs in the true disease-associated ROH (ε = 0, 0.1, or 0.2). W = 100, red solid line, circles; W = 150, blue dashed line, triangles; W = 200, green dotted line, crosses.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0034840.g001