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Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

Figure 3

Glucose, FFA and glycerol in the 3-way cultures in FS, PARS, D1 and D2 conditions.

A) Glucose variations over time. B) Changes in medium glucose concentration with respect to initial media concentration at 48 H (* = p<0.05 vs. D1). C) FFA variations over time. D) Changes in medium FFA concentration with respect to initial media concentration at 48 H (* = p<0.05 vs. FS; ** = p<0.05 vs. D1). E) Glycerol variations over time. F) Changes in medium glycerol concentration with respect to initial media concentration at 48 H (* = p<0.05 vs. D1). In all cases time 0 represents the levels of metabolites in fresh media. Data are expressed as means ± SD (3≤n≤6). Error bars represent the standard deviation.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0034704.g003