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Vascular Dysfunction Induced in Offspring by Maternal Dietary Fat Involves Altered Arterial Polyunsaturated Fatty Acid Biosynthesis

Figure 7

Amount and type of maternal dietary fat induced altered Fads2 promoter methylation.

Values are mean ± SD (n = 6/group). Statistical comparisons were by ANOVA with Tukey's post hoc analysis. Values significantly different (P<0.05) between groups re indicated by different letters. CpG dinucleotides are numbered by their location relative to the transcription start site (bp) (Online Figure 2). Male offspring; (A) CpG −394, (B) CpG −84, (C) CpG −76. Female offspring; (D) CpG −394, (E) CpG −84, (F) CpG −76. (G) Effect of mutation cytosine −394 to adenine on Fads2 promoter activity in response to estrogen. Values are mean ± SD for n = 6 replicate assays. Statistical analysis was by 1-Way ANOVA with Dunnett's post hoc test. ANOVA P = 0.003. Wild type (WT) promoter, M = mutated promoter.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0034492.g007