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Saposin C Coupled Lipid Nanovesicles Specifically Target Arthritic Mouse Joints for Optical Imaging of Disease Severity

Figure 3

CVM signal intensity increases during the course of K/BxN arthritis and correlates with arthritic parameters.

C57Bl/6 mice were given 150 µl of K/BxN sera i.p. and 84 µg of SapC-DOPS-CVM as indicated. (A) Means of back paw intensity values are graphed as columns with error bars representing standard error of the mean. * p<0.05, Students t-test, n≥4 mice per group. For mice treated with K/BxN sera (n = 7) and given SapC-DOPS-CVM the (B) changes in paw thickness and (C) changes in ankle circumference were rounded to the nearest millimeter and the means (+/− SEM) of IVIS® signal intensity for the corresponding paws are graphed as columns. Lines represent linear regression of values in B and C with correlation coefficients indicated. Correlation of arthritis parameters and IVIS® intensity signals in B and C is significant p<0.005, as determined by Pearson Product Moment Correlation and Spearman Rank Order Correlation.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0033966.g003